Bad news for the Ghana team ahead of January's Cup of Nations.
Their captain Stephen Appiah will miss the tournament due to nagging knee injuries.
The Fenerbahce midfielder says he will be out of action for two months.
He's been in Italy for tests on his knee and to get a second opinion, but his doctors have confirmed that he will not be fit.
"The news has come as a bitter blow to Stephen," a statement on the player's website said.
"[He] has been working hard in the last week or so to prove he is fine and fit. Stephen [would] like to say a big thank you to all his fans and well wishers who have sent him get well soon messages in the last few weeks.
"He is very grateful for your support."
The statement also thanked the Ghana Football Association for its patience and understanding. The GFA had given Appiah as much time as he needed to try to prove his fitness.
Appiah's absence will be a huge blow to the host country.
The captain is an inspirational part of the Black Stars lineup.
He led the way as they became the only African side to make it through the knock-out stages of the World Cup in Germany 2006.
He scored the winning penalty in their match against my country, the USA - a victory which sent them through to the last 16 and eventual defeat at the hands of Brazil.
Big blow. Hope you get better soon, Mr. Appiah.